What is euflexxa®?
euflexxa® is an ultra-high purity hyaluronan, also called hyaluronic acid (HA) or sodium hyaluronate. HA is the natural substance found in the fluid that surrounds a healthy knee joint and helps cushion, lubricate, and protect the knee as you move throughout the day. euflexxa® is similar to the human HA found in healthy knee joints. When euflexxa® is injected into the knee joint, it works by replenishing the HA in the knee and restoring the synovial fluid's ability to cushion, lubricate, and protect the knee joint.





Is euflexxa® right for me?
If you have been diagnosed with osteoarthritis (OA) of the knee, euflexxa® may be right for you if you can't get satisfactory pain relief or improvement in activity levels...
  • With over-the-counter pain medications, such as acetaminophen (Tylenol®)
  • With physical therapy, exercise, or weight loss
  • With prescription pain medications
Or, if you can't tolerate...
  • Aspirin
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • COX-2 inhibitors
  • Other pain medications
  • The side effects of prescription pain medications (such as COX-2 inhibitors)
You should not receive treatment with euflexxa® if you have:
  • A known allergy to hyaluronate preparations
  • Knee joint infections, infections or skin disease in the area of the injection site
Be sure to take the euflexxa® Self-Assessment Quiz to help you determine whether you would be a candidate for euflexxa®; therapy. You can then print the results for further consultation with your doctor.

Tylenol is a registered trademark of McNeil Consumer and Specialty Pharmaceuticals.

How is euflexxa® given?
euflexxa® is injected into the knee joint space. Treatment consists of 3 injections-1 injection a week for 3 weeks.

How soon can I expect pain relief from euflexxa®? How long does it last?
While some people experience pain relief after the first injection of euflexxa®, most patients experience significant relief after the third (last) weekly injection. You can expect months of pain relief from euflexxa®, although the duration of relief will vary from person to person.

What are some possible side effects of euflexxa® therapy?
euflexxa® is an ultra-high purity HA and is similar to the HA that already occurs naturally in your body. In clinical trials, few side effects were reported, and those that did occur tended to be mild and transient (they didn't last long). Additionally, 81% of patients reported feeling “satisfied” or “very satisfied” with euflexxa®. In a multicenter clinical study, the only side effect reported in more than 5% of people who used euflexxa® was arthralgia (joint pain) (8.75%).

What else should I know about euflexxa® therapy?
  • Temporary knee pain and swelling in the knee may occur after injection with euflexxa®
  • It is recommended that people avoid any strenuous activities, such as jogging or tennis, within 48 hours following euflexxa® injection
  • While euflexxa® is safe and effective therapy, the safety and effectiveness of euflexxa® have not been established when...
    • Given with other injectable pain medicines
    • Injected into joints other than the knee
    • Given in repeated treatment cycles
  • If you have latex allergies, please consult your physician prior to beginning euflexxa® therapy.
  • euflexxa® may be stored at room temperature or in a refrigerator at 2-25C (36-77F). Protect from light. Do not freeze. If refrigerated, remove from refrigeration at least 20-30 minutes before use.
 euflexxa® success story from Oylmpic Hero, Bruce Jenner

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Important Treatment Consideration

euflexxa® (1% sodium hyaluronate) is indicated for the treatment of knee pain due to osteoarthritis (OA). It is used in people who have failed to get adequate pain relief either from simple pain medications, such as acetaminophen, or from exercise and/or physical therapy.

euflexxa® should not be used in people who have had any previous allergic reaction to hyaluronate preparations or who have knee joint infections or skin diseases in the area of the injection site.

In a randomized, double-blind, multicenter clinical trial, the only adverse event reported with euflexxa® at an incidence greater than 5% was arthralgia (joint pain) (8.75%). Temporary knee pain and swelling may occur after injection with euflexxa®.

The safety and effectiveness of injecting euflexxa® into the knee together with other injectable medications or into joints other than the knee have not been studied. The safety and effectiveness of treatment cycles of fewer than 3 injections or of repeated treatment cycles with euflexxa® have not been established. Strict aseptic technique must be followed to avoid joint infection.